FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

@article{Hbert1994FGF5AA,
  title={FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations},
  author={Jean M H{\'e}bert and Thomas A. Rosenquist and J{\"u}rgen G{\"o}tz and Gail Roberta Martin},
  journal={Cell},
  year={1994},
  volume={78},
  pages={1017-1025}
}
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543 Citations
Highly Influential Citations
29
Background Citations
197
Methods Citations
10
Results Citations
2

543 Citations

Expression and Function of FGF5 Isoform in Hair Growth
TLDR
expression of hepatic growth factor (HGF) gene was increased when FGF5s was overexpressed by adenovirus (Ad) in keratinocytes and BMP6 tend to be decreased in the group transfected with Ad/FGF5 virus than in the control group.
FGF5 and the murine hair cycle
TLDR
Attention is called on to a well-defined mouse model for hair research that uses depilation-induced anagen in adolescent C57BL/6 mice that can be simply controlled by assessing highly characteristic changes in the skin colour.
Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice
TLDR
The results suggest that the relatively mild defects in FGF2 knockout animals are not a consequence of compensation by FGF1 and suggest highly restricted roles for both factors under normal developmental and physiological conditions.
Epidermal Growth Factor as a Biologic Switch in Hair Growth Cycle*
TLDR
It is proposed that epidermal growth factor functions as a biologic switch that is turned on and off in hair follicles at the beginning and end of the anagen phase of the hair cycle, guarding the entry to and exit from theAnagen phase.
CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen
TLDR
Investigation verified that prolonging the anagen phase in rabbits, with decreased BMP2/4 pathway signaling and increased VERSICAN pathway signaling, caused the systemic long hair phenotype, indicating that FGF5 is a negative regulator of hair growth.
FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5
TLDR
The results identify Igfbp5-mediated FGFR2-IIIb signals as a key regulator of the genetic program that controls the structure of the hair shaft medulla.
Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development.
TLDR
It is suggested that FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass and the possibility that this activity is mediated by FGF4 signals transmitted byFGFR2 is raised.
WNT signaling in the control of hair growth and structure.
TLDR
A previously unrecognized role for WNT signaling in the control of hair growth and structure is demonstrated, as well as presenting the first example of a mammalian phenotype resulting from overexpression of a Dvl gene and providing an accessible in vivo system for analysis of mammalian Wnt signaling pathways.
Defective trophoblast function in mice with a targeted mutation of Ets2.
TLDR
Ectopic expression of Ets2 in the deficient fibroblasts restores expression of both matrix metalloproteinases, and is essential for placental function, mediating growth factor signaling to key target genes in different cell types, and for regulating hair development.
Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression
TLDR
The angora mutation provides another useful mouse model for studying the hair cycle and its modulation and was maintained in skin grafted onto C.B-17/Sz-scid/scid mice that had normal pelage hairs and hair cycles, suggesting that circulating or diffusible humoral factors regulating the mouse hair cycle are not involved in this mutation.
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References

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TLDR
Histological examination of skin from various ages of bFGF-treated mice suggested that the growth factor had affected both the initiation and the development of the hair follicles, resulting in a significant delay in the first and subsequent hair cycles when compared to control animals injected with BSA only.
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TLDR
Analysis of the biosynthesis of human fibroblast growth factor-5 at the translational and posttranslational levels suggests that FGF-5 synthesis requires the scanning of ribosomes past the two ORF-1 AUG codons.
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TLDR
All four coat hair types were longer in mice homozygous for angora than in wild-type mice ( + / +), and the activity of the mutant was found to be confined to the epidermis.
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TLDR
A portion of the murine gene is used as probe to detect FGF-5 RNA in adult mouse tissues by both Northern blot and in situ hybridization methods, and it is found that neuronal expression accounts for at least some of the FGF -5 RNA synthesized in the central nervous system.
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