FGF4 Independent Derivation of Trophoblast Stem Cells from the Common Vole

  title={FGF4 Independent Derivation of Trophoblast Stem Cells from the Common Vole},
  author={Elena V. Grigor'eva and Alexander I. Shevchenko and Nina A. Mazurok and Eugeny A. Elisaphenko and Antonina I. Zhelezova and Alexander G. Shilov and Pavel A. Dyban and Andrey P. Dyban and Ekaterina M. Noniashvili and Sergey Ya. Slobodyanyuk and Tatyana B. Nesterova and Neil Brockdorff and Suren M Zakian},
  booktitle={PloS one},
The derivation of stable multipotent trophoblast stem (TS) cell lines from preimplantation, and early postimplantation mouse embryos has been reported previously. FGF4, and its receptor FGFR2, have been identified as embryonic signaling factors responsible for the maintenance of the undifferentiated state of multipotent TS cells. Here we report the derivation of stable TS-like cell lines from the vole M. rossiaemeridionalis, in the absence of FGF4 and heparin. Vole TS-like cells are similar to… CONTINUE READING
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