FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

@inproceedings{Smith2017FGF23IS,
  title={FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts},
  author={Edward R Smith and Sven-Jean Tan and Stephen G. Holt and Tim D. Hewitson},
  booktitle={Scientific Reports},
  year={2017}
}
In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obstruction in the mouse, and pro-fibrotic actions of FGF23 on the fibroblast in vitro. Acute tubulointerstitial injury due to unilateral ureteric obstruction stimulated renal FGF23 synthesis by tubules, and… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Fibroblast growth factor 23 modifies the pharmacological effects of angiotensin receptor blockade in experimental renal fibrosis

de Jong, A M.
Nephrol Dial Transplant, • 2016

Similar Papers

Loading similar papers…