FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy.

@article{Touchberry2013FGF23IA,
  title={FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy.},
  author={Chad D. Touchberry and Troy M Green and Vladimir Tchikrizov and Jaimee E. Mannix and Tiffany F Mao and Brandon W Carney and Magdy Girgis and Robert D. Vincent and Lori A Wetmore and Buddhadeb Dawn and Lynda F. Bonewald and Jason R. Stubbs and Michael J. Wacker},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={304 8},
  pages={E863-73}
}
Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism. Recent observational studies in humans suggest that circulating FGF23 is independently associated with cardiac hypertrophy and increased mortality, but it is unknown whether FGF23 can directly alter cardiac function. We found that FGF23 significantly increased cardiomyocyte cell size in vitro, the expression of gene markers of cardiac hypertrophy, and total… CONTINUE READING

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