FGF23, hypophosphatemia, and rickets: has phosphatonin been found?

  title={FGF23, hypophosphatemia, and rickets: has phosphatonin been found?},
  author={Gordon J. Strewler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 11},
T mineralization of cartilage and bone matrix requires adequate supplies of calcium and phosphate. Among the causes of defective mineralization of bone (osteomalacia) and defective mineralization of cartilage (rickets) are renal phosphate-wasting disorders that produce hypophosphatemia. Phosphate wasting is either inherited as X-linked hypophosphatemic rickets or autosomal dominant hypophosphatemic rickets, or acquired, as can occur in patients with a variety of benign mesenchymal tumors… CONTINUE READING


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