FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain
@article{Umemori2004FGF22AI, title={FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain}, author={Hisashi Umemori and Michael Linhoff and David M. Ornitz and Joshua R. Sanes}, journal={Cell}, year={2004}, volume={118}, pages={257-270} }
272 Citations
FGF ligands emerge as potential specifiers of synaptic identity.
- BiologyCellscience
- 2010
A recent study shows that the decision to form an excitatory vs. inhibitory synapse may to a large extent be determined by the identity of the FGF ligand present at the postsynaptic membrane, establishing FGFs as key target-derived cues that are involved in determining synaptic identity.
Distinct FGFs promote differentiation of excitatory and inhibitory synapses
- BiologyNature
- 2010
It is shown that two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitorypresynaptic terminals, respectively, as target-derived presynaptic organizers.
Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis
- BiologyDevelopment
- 2015
Overlapping but distinct sets of FGF receptors mediate FGF22- and FGF7-dependent excitatory and inhibitory presynaptic differentiation in the mammalian hippocampus, in part through FRS2/PI3K signaling.
Signaling at the vertebrate synapse: new roles for embryonic morphogens?
- BiologyJournal of neurobiology
- 2005
During early embryonic patterning, WNT, TGF-beta, and FGF factors function as typical morphogens in a concentration-dependent manner to regulate cell fate decisions, which raises the provocative idea that these same morphogens might also provide a coordinate system for axons to establish the distance to their targets during axon guidance and synapse formation.
Distinct Target-Derived Signals Organize Formation, Maturation, and Maintenance of Motor Nerve Terminals
- BiologyCell
- 2007
Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum.
- BiologyDevelopmental biology
- 2009
Synaptic Functions of the Neural Cell Adhesion Molecule, NCAM
- Biology
- 2006
In mature brains, NCAM is important for induction of NMDA receptor-dependent long-term potentiation and depression in the CA1 area of the hippocampus, LTP-associated increase in the number of perforated synapses, NMDA receptors-independent mossy fiber LTP, several forms of learning and memory and morphological plasticity in the hypothalamo-neurohypophysial system.
Retrograde signalling at the synapse: a role for Wnt proteins.
- BiologyBiochemical Society transactions
- 2005
The role of the Wnt-Dvl (Dishevelled protein)-GSK-3 beta (glycogen synthase kinase-3beta) signalling pathway in axon remodelling during synapse formation in the central nervous system is discussed.
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