FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

@article{Potthoff2009FGF21IP,
  title={FGF21 induces PGC-1$\alpha$ and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response},
  author={Matthew J Potthoff and T. Inagaki and S. Satapati and Xunshan Ding and T. He and R. Goetz and M. Mohammadi and B. Finck and D. Mangelsdorf and S. Kliewer and S. Burgess},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={10853 - 10858}
}
The liver plays a crucial role in mobilizing energy during nutritional deprivation. During the early stages of fasting, hepatic glycogenolysis is a primary energy source. As fasting progresses and glycogen stores are depleted, hepatic gluconeogenesis and ketogenesis become major energy sources. Here, we show that fibroblast growth factor 21 (FGF21), a hormone that is induced in liver by fasting, induces hepatic expression of peroxisome proliferator-activated receptor γ coactivator protein-1… Expand
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Regulation of energy metabolism by long-chain fatty acids.
Metabolic actions of fibroblast growth factor 21
Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis
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