FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis

@inproceedings{Mottillo2017FGF21DN,
  title={FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis},
  author={Emilio P. Mottillo and Eric MA Desjardins and Andreas M Fritzen and Vito Z. Zou and Justin D. Crane and Julian M. Yabut and Bente Kiens and Derek M. Erion and Adhiraj Lanba and James G. Granneman and Saswata Talukdar and Gregory R Steinberg},
  booktitle={Molecular metabolism},
  year={2017}
}
OBJECTIVE Fibroblast growth factor 21 (FGF21) shows great potential for the treatment of obesity and type 2 diabetes, as its long-acting analogue reduces body weight and improves lipid profiles of participants in clinical studies; however, the intracellular mechanisms mediating these effects are poorly understood. AMP-activated protein kinase (AMPK) is an important energy sensor of the cell and a molecular target for anti-diabetic medications. This work examined the role of AMPK in mediating… CONTINUE READING
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