FGF21 Is an Exocrine Pancreas Secretagogue.

@article{Coate2017FGF21IA,
  title={FGF21 Is an Exocrine Pancreas Secretagogue.},
  author={Katie Colbert Coate and Genaro Hernandez and Curtis A. Thorne and Shengyi Sun and Thao D. V. Le and Kevin Vale and Steven Anthony Kliewer and David J Mangelsdorf},
  journal={Cell metabolism},
  year={2017},
  volume={25 2},
  pages={
          472-480
        }
}
The metabolic stress hormone FGF21 is highly expressed in exocrine pancreas, where its levels are increased by refeeding and chemically induced pancreatitis. However, its function in the exocrine pancreas remains unknown. Here, we show that FGF21 stimulates digestive enzyme secretion from pancreatic acinar cells through an autocrine/paracrine mechanism that requires signaling through a tyrosine kinase receptor complex composed of an FGF receptor and β-Klotho. Mice lacking FGF21 accumulate… CONTINUE READING

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  • 2020
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  • 2019
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References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress

S. H. Kim, K. H. Kim, +5 authors M. S. Lee
  • Diabetologia
  • 2015
VIEW 2 EXCERPTS