FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.

@article{Kiyota2011FGF2GT,
  title={FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.},
  author={Tomomi Kiyota and Kaitlin L. Ingraham and Michael T. Jacobsen and Huangui Xiong and Tsuneya Ikezu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 49},
  pages={E1339-48}
}
The adult hippocampus plays a central role in memory formation, synaptic plasticity, and neurogenesis. The subgranular zone of the dentate gyrus contains neural progenitor cells with self-renewal and multilineage potency. Transgene expression of familial Alzheimer's disease-linked mutants of β-amyloid precursor protein (APP) and presenilin-1 leads to a significant inhibition of neurogenesis, which is potentially linked to age-dependent memory loss. To investigate the effect of neurogenesis on… CONTINUE READING
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