FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways

@article{Wu2011FGF19RC,
  title={FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways},
  author={Ai-Luen Wu and Sally Coulter and Christopher Liddle and Anne B Wong and Jeffrey Eastham-Anderson and Dorothy M. French and Andrew Steele Peterson and Junichiro Sonoda},
  journal={PLoS ONE},
  year={2011},
  volume={6},
  pages={805 - 810}
}
  • Ai-Luen Wu, Sally Coulter, +5 authors Junichiro Sonoda
  • Published in PloS one 2011
  • Medicine, Biology
  • PLoS ONE
  • Fibroblast growth factor 19 (FGF19) is a hormone-like protein that regulates carbohydrate, lipid and bile acid metabolism. At supra-physiological doses, FGF19 also increases hepatocyte proliferation and induces hepatocellular carcinogenesis in mice. Much of FGF19 activity is attributed to the activation of the liver enriched FGF Receptor 4 (FGFR4), although FGF19 can activate other FGFRs in vitro in the presence of the coreceptor βKlotho (KLB). In this report, we investigate the role of FGFR4… CONTINUE READING

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