FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.

Abstract

Fibroblast growth factor (FGF) signaling is involved in skeletal development of the vertebrate. Gain-of-function mutations of FGF receptors (FGFR) cause craniosynostosis, premature fusion of the skull, and dwarfism syndromes. Disruption of Fgfr3 results in prolonged growth of long bones and vertebrae. However, the role that FGFs actually play in skeletal… (More)

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Cite this paper

@article{Ohbayashi2002FGF18IR, title={FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.}, author={Norihiko Ohbayashi and Masaki Shibayama and Yoko Kurotaki and Mayumi Imanishi and Toshihiko Fujimori and Nobuyuki Itoh and Shinji Takada}, journal={Genes & development}, year={2002}, volume={16 7}, pages={870-9} }