FGF10 and FGF21 as regulators in adipocyte development and metabolism.

@article{Ohta2011FGF10AF,
  title={FGF10 and FGF21 as regulators in adipocyte development and metabolism.},
  author={Hiroya Ohta and Morichika Konishi and Nobuyuki Itoh},
  journal={Endocrine, metabolic & immune disorders drug targets},
  year={2011},
  volume={11 4},
  pages={302-9}
}
The FGF family comprises twenty-two evolutionarily related members with diverse functions in development, metabolism, and neuronal activities. FGF10 and FGF21 play unique roles in adipocyte development and metabolism, respectively. FGF10 mediates biological responses by activating FGF receptor 2b (FGFR2b) with heparin/heparan sulfate in a paracrine manner. In contrast, FGF21 mediates biological responses by activating FGFRs with βKlotho in cultured cells. However, FGF21 acts in an autocrine… CONTINUE READING