FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer

  title={FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer},
  author={Sachiyo Nomura and Hideyuki Yoshitomi and Shigetsugu Takano and Takashi Shida and Susumu Kobayashi and Makoto Ohtsuka and Fumio Kimura and Hiroaki Shimizu and Hiroyuki Yoshidome and Atsushi Kato and Masaru Miyazaki},
  journal={British Journal of Cancer},
  pages={305 - 313}
Pancreatic cancer has one of the highest mortalities among all malignancies and there is an urgent need for new therapy. This might be achieved by resolving the detailed biological mechanism, and in this study we examined how pancreatic cancer cells develop aggressive properties by focusing on signalling through the fibroblast growth factor (FGF)10 and FGF receptor (FGFR)2, which play important roles in pancreatic organogenesis. Immunostaining of pancreatic cancer tissues showed that FGFR2 was… CONTINUE READING
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