FGF signalling regulates bone growth through autophagy

  title={FGF signalling regulates bone growth through autophagy},
  author={Laura Cinque and A. Forrester and Rosa Bartolomeo and Maria Svelto and Rossella Venditti and Sandro Montefusco and Elena V. Polishchuk and Edoardo Nusco and Antonio Rossi and Diego Luis Medina and Roman S. Polishchuk and Maria Antonietta De Matteis and Carmine Settembre},
Skeletal growth relies on both biosynthetic and catabolic processes. While the role of the former is clearly established, how the latter contributes to growth-promoting pathways is less understood. Macroautophagy, hereafter referred to as autophagy, is a catabolic process that plays a fundamental part in tissue homeostasis. We investigated the role of autophagy during bone growth, which is mediated by chondrocyte rate of proliferation, hypertrophic differentiation and extracellular matrix (ECM… CONTINUE READING
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