FGF signaling is essential for ophthalmic trigeminal placode cell delamination and differentiation.

@article{Lassiter2009FGFSI,
  title={FGF signaling is essential for ophthalmic trigeminal placode cell delamination and differentiation.},
  author={Rhonda N T Lassiter and Stephanie B Reynolds and Kristopher D Marin and Tyler F Mayo and Michael R. Stark},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={238 5},
  pages={1073-82}
}
The ophthalmic trigeminal (opV) placode gives rise exclusively to sensory neurons of the peripheral nervous system, providing an advantageous model for understanding neurogenesis. The signaling pathways governing opV placode development have only recently begun to be elucidated. Here, we investigate the fibroblast growth factor receptor-4 (FGFR4), an opV expressed gene, to examine if and how FGF signaling regulates opV placode development. After inhibiting FGFR4, Pax3+ opV placode cells failed… CONTINUE READING
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