FGF signaling functions in the hypodermis to regulate fluid balance in C. elegans.

  title={FGF signaling functions in the hypodermis to regulate fluid balance in C. elegans.},
  author={Peng Huang and Michael J. Stern},
  volume={131 11},
Signaling by the Caenorhabditis elegans fibroblast growth factor receptor EGL-15 is activated by LET-756, a fibroblast growth factor, and attenuated by CLR-1, a receptor tyrosine phosphatase. Hyperactive EGL-15 signaling results in a dramatic Clr phenotype characterized by the accumulation of clear fluid within the pseudocoelomic space, suggesting that regulated EGL-15 signaling is essential for fluid homeostasis in C. elegans. To determine the cellular focus of EGL-15 signaling, we identified… CONTINUE READING


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