FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst.

  title={FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst.},
  author={Yojiro Yamanaka and Fredrik Lanner and Janet Rossant},
  volume={137 5},
Primitive endoderm (PE) and epiblast (EPI) are two lineages derived from the inner cell mass (ICM) of the E3.5 blastocyst. Recent studies showed that EPI and PE progenitors expressing the lineage-specific transcriptional factors Nanog and Gata6, respectively, arise progressively as the ICM develops. Subsequent sorting of the two progenitors during blastocyst maturation results in the ormation of morphologically distinct EPI and PE layers at E4.5. It is, however, unknown how the initial… CONTINUE READING
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