FGF modulates the PDGF-driven pathway of oligodendrocyte development

@article{McKinnon1990FGFMT,
  title={FGF modulates the PDGF-driven pathway of oligodendrocyte development},
  author={Randall D. McKinnon and Toshimitsu Matsui and Monique Dubois‐Dalcq and Stuart A. Aaronsont},
  journal={Neuron},
  year={1990},
  volume={5},
  pages={603-614}
}
A Role for Fibroblast Growth Factor in Oligodendrocyte Development
TLDR
It is suggested that bFGF (or a related ligand) in the CNS may sensitize O-2A progenitors to PDGF and thereby initiate their ability to migrate into white matter tracts prior to the onset of myelination.
A role for TGF-beta in oligodendrocyte differentiation
TLDR
TGF- beta produced by O-2A cells may limit PDGF-driven mitosis and promote oligodendrocyte development, and the results suggest that TGF-beta may be an important mediator of oligodendedrocytes differentiation.
Fibroblast Growth Factor-2 Inhibits Myelin Production by Oligodendrocytes in Vivo
TLDR
The results indicate that FGF receptor signalling disrupts myelin production in differentiated oligodendrocytes in vivo and interrupted the transport of myelin-related gene products from the oligodendedrocyte cell body to their myelin sheaths.
PDGF and FGF-2 Signaling in Oligodendrocyte Progenitor Cells: Regulation of Proliferation and Differentiation by Multiple Intracellular Signaling Pathways
TLDR
The molecular mechanism that controls oligodendrocyte lineage progression is operated by at least two signal pathways, which interfere either with proliferation and/or differentiation of oligod endocrine progenitors.
Identification of Small Molecule Compounds that Regulate Pdgfra Transcription in Oligodendrocyte Progenitor Cells
TLDR
There is evidence that suggests that signaling through PDGFRA needs to be inhibited in order for OPC differentiation to occur, and PDGF and its receptor, PDGF receptor A (PDGFRA), are critical regulators of OPC proliferation and their differentiation into myelinating oligodendrocytes.
EGF Enhances Oligodendrogenesis from Glial Progenitor Cells
TLDR
Investigating the role of EGF in early OL development with isolated glial restricted precursor (GRP) cells found that EGF collaborated with Platelet Derived Growth Factor-AA (PDGFaa) to promote the survival and self-renewal ofGRP cells, but predisposed GRP cells to develop into O4− early-stage oligodendrocyte precursor cells (OPCs) in the absence of or PDGFaa.
IGF-I synergizes with FGF-2 to stimulate oligodendrocyte progenitor entry into the cell cycle.
TLDR
Results presented here show that IGF-I significantly amplified the actions of FGF-2 and PDGF to promote DNA synthesis in O-2A progenitors and support a role for IGF-i as a cell cycle progression factor for progenitor cells.
Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration
TLDR
A model is proposed in which the differing effects of PDGF and GGF‐2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development, confirming the migration‐enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF.
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References

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PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage.
TLDR
Radiolabelled PDGF is used to show that O-2A progenitor cells have PDGF receptors, suggesting that these cells respond directly to PDGF, which is similar to the type A PDGF receptor previously described on human fibroblasts.
PDGF and intracellular signaling in the timing of oligodendrocyte differentiation
TLDR
It is shown that although PDGF does not stimulate newly formed oligodendrocytes to synthesize DNA, it induces an increase in cytosolic Ca2+ in these cells, and the most parsimonious explanation for these results is that O-2A progenitor cells become mitotically unresponsive to PDGF because the intracellular signaling pathways are blocked downstream from the receptor and some of the early events that are triggered by receptor activation are blocked.
Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil
TLDR
It is found that platelet-derived growth factor mimics the effects of type-1 astrocytes on O-2A progenitor cells, and antibodies to PDGF block the effects.
PDGF A chain homodimers drive proliferation of bipotential (O‐2A) glial progenitor cells in the developing rat optic nerve.
TLDR
The results suggest that O‐2A progenitor cells possess predominantly type A receptors, and proliferate during development in response to PDGF‐AA secreted by type 1 astrocytes, suggesting that the major form of PDGF in the central nervous system is a homodimer of A chains.
Epidermal growth factor inhibits the expression of myelin basic protein in oligodendrocytes
TLDR
It was found that MBP could be down‐regulated in mature MBP+ oligodendrocytes, and the action of EGF in these cultures could be mimicked by transforming growth factor‐α (TGFα).
Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro
TLDR
IGF‐I promotes proliferation of precursor cells in the O‐2A lineage, and it induces precursors to become committed to develop into oligodendrocytes in cultures of cells explanted from perinatal rat cerebrum.
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