FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk

@inproceedings{MartnezMorales2011FGFAR,
  title={FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk},
  author={Patricia L. Mart{\'i}nez-Morales and Ruth Diez del Corral and Isabel Olivera-Mart{\'i}nez and Alejandra C. Quiroga and Raman M Das and Julio A. Barbas and Kate G Storey and Aixa V. Morales},
  booktitle={The Journal of cell biology},
  year={2011}
}
Coordination between functionally related adjacent tissues is essential during development. For example, formation of trunk neural crest cells (NCCs) is highly influenced by the adjacent mesoderm, but the molecular mechanism involved is not well understood. As part of this mechanism, fibroblast growth factor (FGF) and retinoic acid (RA) mesodermal gradients control the onset of neurogenesis in the extending neural tube. In this paper, using gain- and loss-of-function experiments, we show that… CONTINUE READING
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