FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

@inproceedings{Ficz2013FGFSI,
  title={FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency},
  author={Gabriella Ficz and Timothy Alexander Hore and F{\'a}tima Aparecida dos Santos and Heather J Lee and Wendy Lee Dean and Julia Arand and Felix Krueger and David Oxley and Yu-Lee Paul and J{\"o}rn Walter and Simon J Cook and Simon R. Andrews and Miguel R Branco and Wolf Reik},
  booktitle={Cell stem cell},
  year={2013}
}
Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos and is linked with pluripotency. Inhibition of Erk1/2 and Gsk3β signaling in mouse embryonic stem cells (ESCs) by small-molecule inhibitors (called 2i) has recently been shown to induce hypomethylation. We show by whole-genome bisulphite sequencing that 2i induces rapid and genome-wide demethylation on a scale and pattern similar to that in migratory PGCs and early embryos. Major satellites… CONTINUE READING
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