FGF-4 regulates expression of Evx-1 in the developing mouse limb.

@article{Niswander1993FGF4RE,
  title={FGF-4 regulates expression of Evx-1 in the developing mouse limb.},
  author={Lee Niswander and Gail R. Martin},
  journal={Development},
  year={1993},
  volume={119 1},
  pages={287-94}
}
We describe here the temporal and spatial pattern of expression of Evx-1, a murine homolog of the Drosophila even-skipped gene, in the developing limb bud. Evx-1 RNA is first detected in distal limb (progress zone) mesenchyme shortly after the formation of the apical ectodermal ridge. The level of Evx-1 RNA increases during the next 24 hours of development, and then decreases in the subsequent 24 hours, such that by the time the ridge regresses Evx-1 RNA is undetectable. At all these stages… CONTINUE READING

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in the mouse

  • L. Niswander, G. R. Martin
  • 1993

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