FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease.

  title={FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease.},
  author={Mahmut Ilker Yilmaz and A. Sait Sonmez and Mutlu Sağlam and H. Ruhi Yaman and Selim Kiliç and Erkan Demirkaya and Tayfun Eyileten and Kayser Cağlar and Yusuf Oğuz and A. Gural Vural and Mujdat Yenicesu and Carmine Zoccali},
  journal={Kidney international},
  volume={78 7},
Studies in animals show that fibroblast growth factor (FGF)-23 interferes with vascular reactivity induced by the nitric oxide (NO) system. To investigate the relationship between circulating FGF-23 levels and the response of forearm blood flow to ischemia (flow-mediated vasodilatation, FMD) and nitroglycerin, we tested 183 patients with stage 3-4 chronic kidney disease (CKD). None of them had cardiovascular complications or were taking drugs interfering with vascular function. Patients with… CONTINUE READING


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