FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.

@article{Kharitonenkov2008FGF21FGF21RI,
  title={FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.},
  author={Alexei Kharitonenkov and James D. Dunbar and Holly A. Bina and Stuart Bright and Julie S. Moyers and Chen Zhang and Liyun Ding and Radmila Micanovic and Sean F Mehrbod and Michael D. Knierman and John E. S. Hale and Tamer Coskun and Armen B. Shanafelt},
  journal={Journal of cellular physiology},
  year={2008},
  volume={215 1},
  pages={1-7}
}
Fibroblast growth factor-21 (FGF-21) is a metabolic regulator that can influence glucose and lipid control in diabetic rodents and primates. We demonstrate that betaKlotho is an integral part of an activated FGF-21-betaKlotho-FGF receptor (FGFR) complex thus a critical subunit of the FGF-21 receptor. Cells lacking betaKlotho did not respond to FGF-21; the introduction of betaKlotho to these cells conferred FGF-21-responsiveness and recapitulated the entire scope of FGF-21 signaling observed in… CONTINUE READING

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