FGF-2 stimulation affects calvarial osteoblast biology: quantitative analysis of nine genes important for cranial suture biology by real-time reverse transcription polymerase chain reaction.

@article{Mathy2003FGF2SA,
  title={FGF-2 stimulation affects calvarial osteoblast biology: quantitative analysis of nine genes important for cranial suture biology by real-time reverse transcription polymerase chain reaction.},
  author={Jonathan A. Mathy and Kelly A Lenton and Randall P Nacamuli and Kenton D Fong and Hanjoon M Song and Tony D Fang and George P. Yang and Michael Thornton Longaker},
  journal={Plastic and reconstructive surgery},
  year={2003},
  volume={112 2},
  pages={528-39}
}
Appropriately timed closure of the cranial sutures is a critical factor in normal postnatal morphogenesis of the cranial vault. Suture patency is necessary to permit rapid neonatal expansion of the cerebral hemispheres, and later ossification is important for bony protection of the cerebrum. Premature suture ossification (craniosynostosis) leads to myriad adverse functional and developmental consequences. Several murine studies have implicated dura-derived fibroblast growth factor-2 (FGF-2… CONTINUE READING