FGF-2 influences cell movements and gene expression during limb development.

  title={FGF-2 influences cell movements and gene expression during limb development.},
  author={S C Li and Rosalie Anderson and Angie Reginelli and Ken Muneoka},
  journal={The Journal of experimental zoology},
  volume={274 4},
FGF-2 is proposed to be an important ectodermal signal directing limb outgrowth and patterning. Consistent with this hypothesis we show that ectopic application of FGF-2 can maintain the apical ectodermal ridge (AER)-dependent expression of Sonic hedgehog (Shh), and AER-dependent zone of polarizing activity (ZPA) signaling. We also find that ectopic FGF-2 applied to the posterior wing bud caused a dramatic change in the morphology of the limb bud, and results in limbs that display a reduction… CONTINUE READING
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