FGF-2 counteracts loss of TGFbeta affected cells from rat lens explants: implications for PCO (after cataract).

@article{Mansfield2004FGF2CL,
  title={FGF-2 counteracts loss of TGFbeta affected cells from rat lens explants: implications for PCO (after cataract).},
  author={Kylie Jan Mansfield and Anna Cerra and Coral G. Chamberlain},
  journal={Molecular vision},
  year={2004},
  volume={10},
  pages={521-32}
}
PURPOSE While cataract surgery initially benefits most patients, many suffer secondary loss of vision because of posterior capsule opacification (PCO). Lens epithelial cells left behind at surgery become aberrant and migrate into the light path. TGF-beta (TGFbeta) appears to play a key role in this process by inducing the cells to undergo an epithelial-mesenchymal transition. Paradoxically, it also typically induces them to undergo apoptotic death. The present study was undertaken to… CONTINUE READING

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