FGF-2 acts through an ERK1/2 intracellular pathway to affect osteoblast differentiation.

@article{Spector2005FGF2AT,
  title={FGF-2 acts through an ERK1/2 intracellular pathway to affect osteoblast differentiation.},
  author={Jason A. Spector and Jonathan A. Mathy and Stephen M. Warren and Randall P Nacamuli and Hanjoon M Song and Kelly A Lenton and Kenton D Fong and Dongyu T Fang and Michael Thornton Longaker},
  journal={Plastic and reconstructive surgery},
  year={2005},
  volume={115 3},
  pages={838-52}
}
An abundance of genetic and experimental data have suggested that fibroblast growth factor (FGF) signaling plays a central role in physiological and pathological cranial suture fusion. Although alterations in the differentiation and proliferation of sutural osteoblasts may be a key mediator of this process, the mechanisms by which FGF signaling regulates osteoblast differentiation remain incompletely understood. In the current study, the authors show that recombinant human FGF-2 alters… CONTINUE READING

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