FGF-2 Up-regulation and proliferation of neural progenitors in the regenerating amphibian spinal cord in vivo.

@article{Zhang2000FGF2UA,
  title={FGF-2 Up-regulation and proliferation of neural progenitors in the regenerating amphibian spinal cord in vivo.},
  author={Fang Zhang and Jonathan Clarke and Patrizia Ferretti},
  journal={Developmental biology},
  year={2000},
  volume={225 2},
  pages={381-91}
}
Regeneration of the spinal cord occurs spontaneously in adult urodele amphibians. The key cells in this regenerative process appear to be the ependymal cells that following injury migrate and proliferate to form the ependymal tube from which the spinal cord regenerates. Very little is known about the signal(s) that initiates and maintains the proliferative response of these cells. Fibroblast growth factor 2 (FGF-2) has been shown to play a role in maintaining neural progenitor cell cycling in… CONTINUE READING