FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain

@article{Maurer2003FEVAA,
  title={FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain},
  author={Philippe Maurer and France T'sas and Laurent Coutte and Nathalie Callens and Carmen Brenner and Carine van Lint and Yvan de Launoit and J l Baert},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={3319-3329}
}
Although most Ets transcription factors have been characterized as transcriptional activators, some of them display repressor activity. Here we characterize an Ets-family member, the very specifically expressed human Fifth Ewing Variant (FEV), as a transcriptional repressor. We show that among a broad range of human cell lines, only Dami megakaryocytic cells express FEV. This nuclear protein binds to Ets-binding sites, such as that of the human ICAM-1 promoter. We used this promoter to… CONTINUE READING

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