FETAL ALCOHOL SYNDROME IS NOW LEADING CAUSE OF MENTAL RETARDATION

@article{Abel1986FETALAS,
  title={FETAL ALCOHOL SYNDROME IS NOW LEADING CAUSE OF MENTAL RETARDATION},
  author={E. Abel and R. Sokol},
  journal={The Lancet},
  year={1986},
  volume={328}
}
Maternal Alcohol Abuse and Fetal Alcohol Spectrum Disorder
TLDR
Research results in the areas of drug treatment and developmental outcomes are reviewed and recommendations for service provision to both mothers with alcohol abuse problems and individuals with Fetal Alcohol Spectrum Disorder are made. Expand
Long-Lasting Effects of Prenatal Ethanol Exposure on Fear Learning and Development of the Amygdala
TLDR
Results from this study will provide insight on the neurobiological and behavioral effects of PrEE and provide new information on developmental trajectories of brain dysfunction in people prenatally exposed to ethanol. Expand
FETAL ALCOHOL SYNDROME
This review summarizes the literature on the fetal disorders that arise under the influence of prenatal alcoholism, on the criteria for diagnosis, pathogenesis, behavioral disorders, treatment andExpand
Selective underexpression of Kv3.2 and Kv3.4 channels in the cortex of rats exposed to ethanol during early postnatal life
TLDR
An increased susceptibility to apoptotic neuronal death after early postnatal exposure to ethanol was confirmed by the lower bcl-2/bax ratio observed in alcohol-treated animals, and the lack of upregulation in the model argues against their involvement in the mechanism leading to alcohol-induced apoptosis. Expand
Brain microstructure is related to math ability in children with fetal alcohol spectrum disorder.
TLDR
The results highlight the consistent importance of the left parietal area for mathematical tasks across various populations, and also demonstrate other regions that may be specific to mathematical processing in children with FASD. Expand
Cerebral palsy and alcohol consumption during pregnancy: is there a connection?
  • E. Abel
  • Medicine
  • Alcohol and alcoholism
  • 2010
TLDR
These neurodevelopmental disorders and other wide-ranging physical and behavioral problems occurring in conjunction with or in the absence of classic FAS features are now subsumed under the broader umbrella term, fetal alcohol spectrum disorder (FASD). Expand
Fatty Acid Ethyl Esters (FAEE), A Biomarker of Alcohol Exposure: Hope for a Silent Epidemic of Fetal Alcohol Affected Children
TLDR
This thesis fills a translational gap of research between the development of the FAEE hair test and its application in the context of FASD, and reports a positive dose-concentration relationship between alcohol exposure and hair FAEE, in the human, and the guinea pig. Expand
Alcohol Consumption and Abstention among Pregnant Japanese Women
TLDR
Significant associations were recognized between higher education and both alcohol consumption during pregnancy and abstention after pregnancy confirmation, whereas abstention was significantly associated with less frequent alcohol consumption and knowledge regarding the risk of alcohol consumption. Expand
Ameliorating effects of preadolescent aniracetam treatment on prenatal ethanol-induced impairment in AMPA receptor activity
TLDR
Rats exposed to ethanol in utero were treated with aniracetam, and subsequently exhibited persistent improvement in mEPSC amplitude, frequency, and decay time, suggesting that anir acetam ameliorates prenatal ethanol-induced deficits through modifications at the single channel level. Expand
Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
TLDR
It is demonstrated ethanol alters the expression of specific molecules in the cerebellum understudied in FASD, but crucial for immune responses, and suggests that ethanol modulation of CX3CL1‐CX3CR1 signaling may contribute to cerebellar neuroinflammation and neuropathology. Expand
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References

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Mental retardation in over half-a-million consecutive livebirths: an epidemiological study.
TLDR
The minimum prevalence for all levels of retardation among the 15- to 29-year age group, where ascertainment was best, was 7.7 per 1,000, and data were presented on lagtime (time from birth until a retarded person is identified in association with the level of functioning and the presence of disabilities in addition to mental retardation). Expand
PERSPECTIVES ON THE CAUSE AND FREQUENCY OF THE FETAL ALCOHOL SYNDROME
TLDR
The present evidence favors ethanol as the cause for the adverse effects on morphogenesis that constitute the fetal alcohol syndrome, and it is recommended that chronically alcoholic women be on effective birth control measures. Expand