FEM1A is a candidate gene for polycystic ovary syndrome.

  title={FEM1A is a candidate gene for polycystic ovary syndrome.},
  author={Joseph F. Maher and Randall S. Hines and Walter Futterweit and Shawana Crawford and Deyin Lu and Peidong Shen and Peter J. Oefner and Mohammed Ahmed Kazi and James G. Wilson and Jose S. Subauste and Bryan D. Cowan},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  volume={21 6},
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, and is characterized by infertility, hyperandrogenism and insulin resistance in skeletal muscle. There is evidence for a PCOS gene localized to chromosome 19p13.3. The FEMIA gene maps to chromosome 19p13.3 and is highly expressed in skeletal muscle. FEMIA is a homolog of fem-1, a sex-determination gene of Caenorhabditis elegans that controls masculinization. In a pilot study of Caucasian PCOS… CONTINUE READING


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