FE 200 440: a selective oxytocin antagonist on the term-pregnant human uterus.


OBJECTIVE To compare a newly developed oxytocin antagonist, FE 200 440, with atosiban and ANTAG III, as to potency and selectivity of inhibitory effects on oxytocin- and vasopressin-induced myometrial responses. FE 200 440 has high affinity for the human cloned oxytocin receptor, approximately 300-fold that for the vasopressin V(1a) receptor, whereas… (More)