FDM: a graph-based statistical method to detect differential transcription using RNA-seq data

@inproceedings{Singh2011FDMAG,
  title={FDM: a graph-based statistical method to detect differential transcription using RNA-seq data},
  author={Darshan Singh and Christian F. Orellana and Yin Hu and Corbin D. Jones and Yufeng Liu and Derek Y. Chiang and Jinze Liu and Jan Prins},
  booktitle={Bioinformatics},
  year={2011}
}
MOTIVATION In eukaryotic cells, alternative splicing expands the diversity of RNA transcripts and plays an important role in tissue-specific differentiation, and can be misregulated in disease. To understand these processes, there is a great need for methods to detect differential transcription between samples. Our focus is on samples observed using short-read RNA sequencing (RNA-seq). METHODS We characterize differential transcription between two samples as the difference in the relative… CONTINUE READING
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