FDA approves 'farmaceutical' drug from transgenic chickens

@article{Sheridan2016FDAA,
  title={FDA approves 'farmaceutical' drug from transgenic chickens},
  author={Cormac Sheridan},
  journal={Nature Biotechnology},
  year={2016},
  volume={34},
  pages={117-119}
}
  • C. Sheridan
  • Published 5 February 2016
  • Biology
  • Nature Biotechnology
process and by the low yields obtained from those animals that were successfully modified. Despite subsequent improvements in both, the project never yielded a commercial product (Nat. Biotechnol. 20, 484–487, 2002). PPL Therapeutics, the company spun out of the Roslin Institute in Edinburgh, Scotland on the back of Ian Wilmut’s and Keith Campbell’s pioneering work in mammalian SCNT, also failed to make headway in its efforts to produce a1-antitrypsin (AAT) in the milk of transgenic sheep… 

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References

Large scale production of recombinant human lactoferrin in the milk of transgenic cows

Although natural hLF from human milk and rhLF underwent differential N-linked glycosylation, they were equally effective in three different in vivo infection models employing immunocompetent and leukocytopenic mice, and showed similar localization at sites of infection.