FCS study of the thermodynamics of membrane protein insertion into the lipid bilayer chaperoned by fluorinated surfactants.

@article{Posokhov2008FCSSO,
  title={FCS study of the thermodynamics of membrane protein insertion into the lipid bilayer chaperoned by fluorinated surfactants.},
  author={Yevgen O. Posokhov and Mykola V. Rodnin and Somes Kumar Das and Bernard Pucci and Alexey S. Ladokhin},
  journal={Biophysical journal},
  year={2008},
  volume={95 8},
  pages={L54-6}
}
Experimental determination of the free energy (DeltaG) stabilizing the structure of membrane proteins (MPs) in their native environment has been hampered by the aggregation and precipitation of MPs outside the lipid bilayer. We recently demonstrated that the latter process can be prevented by the use of fluorinated surfactants, FTACs, that act as chaperones for MP insertion without partitioning in the membrane themselves. Here we combine the advantages of the chaperone-like ability of FTACs… CONTINUE READING

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