FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.

@article{Mechetina2002FCRLAN,
  title={FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.},
  author={Ludmila V. Mechetina and Alexander M. Najakshin and Olga Y. Volkova and Sergei V. Guselnikov and Rafik Z Faizulin and Boris Y. Alabyev and Nikolai A. Chikaev and Maria S Vinogradova and Alexander V. Taranin},
  journal={European journal of immunology},
  year={2002},
  volume={32 1},
  pages={87-96}
}
A novel conserved member of the leukocyte Fc receptor (FcR) family was identified in human and mouse. The presumably secreted protein, designated FCRL (FcR-like) is comprised of four domains. The three N-terminal domains are related to the extracellular region of FcgammaRI, with the second (35-37% residue identity) and the third (46-52%) domains showing highest similarity. The C-terminal domain is a unique sequence enriched with proline residues. In humans, alternative transcripts for six FCRL… CONTINUE READING
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