FCHo proteins are nucleators of clathrin-mediated endocytosis.

  title={FCHo proteins are nucleators of clathrin-mediated endocytosis.},
  author={W Mike Henne and Emmanuel Boucrot and Michael Meinecke and Emma Evergren and Yvonne Vallis and Rohit Mittal and Harvey T McMahon},
  volume={328 5983},
Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors destined for internalization. However, here we report that the membrane-sculpting F-BAR domain-containing Fer/Cip4 homology domain-only proteins 1 and 2 (FCHo1/2) were required for plasma membrane clathrin-coated vesicle (CCV) budding and marked sites of CCV formation. Changes in FCHo1/2 expression levels… CONTINUE READING
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