FBXW7 negatively regulates ENO1 expression and function in colorectal cancer

  title={FBXW7 negatively regulates ENO1 expression and function in colorectal cancer},
  author={Panpan Zhan and Yuli Wang and Shihu Zhao and Chun-yan Liu and Yun-Shan Wang and Mingxin Wen and Jian-Hua Mao and Guangwei Wei and Pengju Zhang},
  journal={Laboratory Investigation},
FBXW7 (F-box and WD40 domain protein 7) is a tumor suppressor frequently inactivated in human cancers. The precise molecular mechanisms by which FBXW7 exerts antitumor activity remain under intensive investigation and are thought to relate in part to FBXW7-mediated destruction of key cancer-relevant proteins. Enolase 1 (ENO1) possesses oncogenic activity and is often overexpressed in various human cancers, besides its critical role in glycolysis. However, the detailed regulatory mechanisms of… CONTINUE READING
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