FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.

Abstract

Mitotic progression is regulated by ubiquitin E3 ligase complexes to carefully orchestrate eukaryotic cell division. Here, we show that a relatively new E3 ligase component belonging to the SCF (Skip-Cullin1-F-box protein) E3 ligase family, SCF (FBXL2) , impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation. Both cyclin D3 and… (More)
DOI: 10.4161/cc.10.20.17742

Topics

Cite this paper

@article{Chen2011FBXL2IA, title={FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.}, author={Bill B Chen and Jennifer R. Glasser and Tiffany A. Coon and Rama K Mallampalli}, journal={Cell cycle}, year={2011}, volume={10 20}, pages={3487-94} }