FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline.

@article{Suh2009FBFAI,
  title={FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline.},
  author={Nayoung Suh and Sarah L. Crittenden and Aaron C Goldstrohm and Brad A Hook and Beth A Thompson and Marvin Wickens and Judith Kimble},
  journal={Genetics},
  year={2009},
  volume={181 4},
  pages={1249-60}
}
FBF, a PUF RNA-binding protein, is a key regulator of the mitosis/meiosis decision in the Caenorhabditis elegans germline. Genetically, FBF has a dual role in this decision: it maintains germ cells in mitosis, but it also facilitates entry into meiosis. In this article, we explore the molecular basis of that dual role. Previous work showed that FBF downregulates gld-1 expression to promote mitosis and that the GLD-2 poly(A) polymerase upregulates gld-1 expression to reinforce the decision to… CONTINUE READING