FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.

@article{Wu2006FATP1IA,
  title={FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.},
  author={Qiwei Wu and Angelica M. Ortegon and Bernice Tsang and Holger Doege and Kenneth R. Feingold and Andreas Stahl},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 9},
  pages={3455-67}
}
Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues. In adipocytes and skeletal muscle, FATP1 translocates from an intracellular compartment to the plasma membrane in response to insulin. Here we show that insulin-stimulated fatty acid uptake is completely abolished in FATP1-null adipocytes and greatly reduced in skeletal muscle of FATP1-knockout… CONTINUE READING

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