FAT10 plays a role in the regulation of chromosomal stability.

@article{Ren2006FAT10PA,
  title={FAT10 plays a role in the regulation of chromosomal stability.},
  author={Jianwei Ren and Alison Kan and Siew Hong Leong and London Lucien Ooi and K. T. Jeang and Samuel S Chong and Oi Lian Kon and Caroline G L Lee},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 16},
  pages={
          11413-21
        }
}
Aneuploidy is a key process in tumorigenesis. Dysfunction of the mitotic spindle checkpoint proteins has been implicated as a cause of aneuploidy in cells. We have previously reported that FAT10, a member of the ubiquitin-like modifier family of proteins, is overexpressed in several gastrointestinal and gynecological cancers. Here we show that FAT10 interacts with MAD2, a spindle checkpoint protein, during mitosis. Notably, we show that localization of MAD2 at the kinetochore during the… CONTINUE READING
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