FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination

@inproceedings{Buchsbaum2012FAT10IA,
  title={FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination},
  author={Samuel Buchsbaum and Beatrice Bercovich and Aaron Ciechanover},
  booktitle={Molecular biology of the cell},
  year={2012}
}
FAT10 is a ubiquitin-like protein modifier that is induced in vertebrates following certain inflammatory stimuli. Its functions and the repertoire of its target substrates have remained elusive. In contrast to ubiquitin, its cellular abundance is tightly controlled by both transcriptional and posttranslational regulation, and it was reported to be rapidly degraded by the proteasome. Here we provide data to indicate that the degradation of FAT10 requires ubiquitination: degradation was inhibited… CONTINUE READING

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