FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway.

  title={FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway.},
  author={Erich Gulbins and Robert Bissonnette and Artin Mahboubi and St{\'e}phane Andr{\'e} Martin and Wakako Nishioka and Thomas Levin Brunner and Gottfried Baier and Gabriele Baier-Bitterlich and Christopher Byrd and François Lang},
  volume={2 4},
Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pathway, since inhibition of Ras by neutralizing antibody or a dominant-negative Ras mutant interfered with Fas-induced apoptosis. Furthermore, ligation of Fas also resulted in… CONTINUE READING

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