FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis

@article{Bandyopadhyay2005FASEI,
  title={FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis},
  author={Sucharita Bandyopadhyay and Sudha K. Pai and Misako Watabe and Steven C. Gross and Shigeru Hirota and Sadahiro Hosobe and Taisei Tsukada and Kunio Miura and Ken Saito and Stephen J. Markwell and Ying Wang and Jodi I. Huggenvik and Mary E. Pauza and Megumi Iiizumi and Kounosuke Watabe},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={5389-5395}
}
Fatty acid synthase (FAS), a key enzyme of the fatty acid biosynthetic pathway, has been shown to be overexpressed in various types of human cancer and is, therefore, considered to be an attractive target for anticancer therapy. However, the exact mechanism of overexpression of the FAS gene in tumor cells is not well understood. In this report, we demonstrate that the expression of the tumor suppressor gene PTEN has a significant inverse correlation with FAS expression in the case of prostate… CONTINUE READING

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