FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis

@article{Bandyopadhyay2005FASEI,
  title={FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis},
  author={S. Bandyopadhyay and S. K. Pai and M. Watabe and S. Gross and S. Hirota and S. Hosobe and T. Tsukada and K. Miura and K. Saito and S. Markwell and Y. Wang and J. Huggenvik and M. Pauza and Megumi Iiizumi and K. Watabe},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={5389-5395}
}
Fatty acid synthase (FAS), a key enzyme of the fatty acid biosynthetic pathway, has been shown to be overexpressed in various types of human cancer and is, therefore, considered to be an attractive target for anticancer therapy. However, the exact mechanism of overexpression of the FAS gene in tumor cells is not well understood. In this report, we demonstrate that the expression of the tumor suppressor gene PTEN has a significant inverse correlation with FAS expression in the case of prostate… Expand
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