FAS Associated Phosphatase (FAP-1) Blocks Apoptosis of Astrocytomas through Dephosphorylation of FAS

@article{Foehr2004FASAP,
  title={FAS Associated Phosphatase (FAP-1) Blocks Apoptosis of Astrocytomas through Dephosphorylation of FAS},
  author={Erik D. Foehr and Gustavo Lorente and Valerie A M Vincent and Karoly Nikolich and Roman Urfer},
  journal={Journal of Neuro-Oncology},
  year={2004},
  volume={74},
  pages={241-248}
}
Astrocytomas are the most common primary tumor of the adult human central nervous system. Despite efforts to develop more effective clinical treatment strategies, median survival time for patients with the most severe form of astrocytoma, glioblastoma multiforme (GBM), remains about one year. Astrocytomas are resistant to cytotoxic therapy in general and radiation therapy in particular, greatly limiting treatment options. One reason for this seems to be defects in the pathways controlling… CONTINUE READING

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