FARMAKOLOŠKI IN VITRO MODELI ZA PREDKLINIČKO ISPITIVANJE LEKOVA - PRIMER hSERT TRANSFICIRANIH HUMANIH EMBRIONALNIH ĆELIJA BUBREGA

@article{Jakovljevic2013FARMAKOLOKIIV,
  title={FARMAKOLO{\vS}KI IN VITRO MODELI ZA PREDKLINI{\vC}KO ISPITIVANJE LEKOVA - PRIMER hSERT TRANSFICIRANIH HUMANIH EMBRIONALNIH {\'C}ELIJA BUBREGA},
  author={Mihajlo Jakovljevic and Olivera Milovanovic},
  journal={Acta Medica Medianae},
  year={2013},
  pages={34-38}
}
Predkliničko testiranje lekova je važan segment ispitivanja efikasnosti i bezbednosti leka u pretpostavljenoj indikaciji. Njegova svrha je u prikupljanju značajnog kvantuma informacija o leku pre ulaska u kliničku fazu ispitivanja na humanim subjektima. Pored ispitivanja na mikroorganizmima i animalnim modelima poslednjih decenija je usvojena tehnologija rada sa kultivisanim ćelijskim linijama humanog porekla. One pružaju jedinstvenu mogućnost ispitivanja uticaja leka na biohemijske transportne… 

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