FAR1 links the signal transduction pathway to the cell cycle machinery in yeast.

@article{Peter1993FAR1LT,
  title={FAR1 links the signal transduction pathway to the cell cycle machinery in yeast.},
  author={Martin Peter and Anton Gartner and Joe Horecka and Gustav Ammerer and Ira Herskowitz},
  journal={Cell},
  year={1993},
  volume={73 4},
  pages={747-60}
}
Alpha factor induces arrest of yeast a cells in G1 and transcription of genes involved in mating. Prior work indicates that FUS3, a member of the MAP kinase family, and FAR1, whose molecular activity is unknown, contribute to cell cycle arrest by inhibiting G1 cyclins. Here we show that FAR1 is a substrate for FUS3 and that this phosphorylation regulates association of FAR1 with CDC28-CLN2 kinase. We show also that FAR1 is phosphorylated in vitro by the CDC28-CLN2 complex and in vivo in a CDC28… CONTINUE READING
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