FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.

@article{RamirezMontagut2004FAPalphaAS,
  title={FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.},
  author={Teresa Ramirez-Montagut and Nathalie E. Blach{\`e}re and Elena V Sviderskaya and Dorothy C Bennett and Wolfgang J. Rettig and Pilar Garin-Chesa and Alan N. Houghton},
  journal={Oncogene},
  year={2004},
  volume={23 32},
  pages={5435-46}
}
Fibroblast activation protein-alpha (FAP) is a cell surface serine protease expressed at sites of tissue remodeling in embryonic development. FAP is not expressed by mature somatic tissues except activated melanocytes and fibroblasts in wound healing or tumor stroma. FAP expression is specifically silenced in proliferating melanocytic cells during malignant transformation. To study the role of FAP as a tumor suppressor, the gene for mouse fap was cloned and mutated at the catalytic domain (FAP… CONTINUE READING

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